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Grade 12
1000+ Students

SBI4U – Grade 12 Biology Online Course (Ontario)

SBI4U is Ontario’s Grade 12 university-preparation biology course and a required credit for life sciences, health sciences, kinesiology and nursing programs. It covers biochemistry, metabolic processes, molecular genetics, homeostasis and population dynamics, with simple at-home labs such as DNA extraction and interactive simulations. Ontario eSecondary School (OES) offers SBI4U fully online and self-paced, with marking and support from Ontario Certified Teachers.

Credit: 1.0
Prerequisite: SBI3U
110 course hours
Registration open year-round

💻 Fulfills OSSD Online Graduation Requirement

Diving into the SBI4U course online provides an opportunity for students to explore the intricate workings of biological systems at an advanced level. With a curriculum that navigates through the core areas of biochemistry, metabolic processes, molecular genetics, homeostasis, and population dynamics, grade 12 Biology is designed to blend theoretical knowledge with practical application seamlessly. Students engaging with grade 12 Biology are tasked with not only understanding these complex subjects but also applying them in investigative scenarios. The course sets a clear path towards building the skills and knowledge essential for further studies in life sciences and adjacent fields, positioning grade 12 Biology participants for future inquiry and innovation in the field of biology.

110 course hours
Assignments
Final Exam
Interactive Submissions
Simulation Labs
Language: English
24/7 Tutoring
Developed by: D. Fairfax (OCT)
University
Prerequisite: SBI3U

SBI4U Course outline — 6 units, 110 hours

Full unit-by-unit breakdown.

Functional groups · carbohydrates, lipids, proteins and nucleic acids · enzyme activity and the factors that affect it · biochemical reactions

Identify the structures, functions and chemical properties of the biological molecules behind common cellular processes, and why they matter for normal cell function. Then analyse how enzyme activity is applied in the food and pharmaceutical industries.

Key topics

Functional groups · carbohydrates, lipids, proteins and nucleic acids · enzyme activity and the factors that affect it · biochemical reactions

Assessed by

Research article summary · enzyme lab · proctored unit test · end-of-unit conference

Glycolysis · Krebs cycle · electron transport · photosynthesis · medical and technological applications

Trace cellular respiration and photosynthesis through the organelles and metabolic reactions involved, and understand why these reactions keep cells functioning. Analyse medical and technological applications of both processes.

Key topics

Glycolysis · Krebs cycle · electron transport · photosynthesis · medical and technological applications

Assessed by

Cellular respiration research report · 1-on-1 teacher interview · proctored unit test

DNA structure and replication · transcription and translation · mutations and disease · DNA profiling and biotechnology

Follow the scientific contributions that led to the discovery of DNA and its function, then work through DNA replication and protein synthesis, with emphasis on how mutations affect protein function and disease. Analyse common biotechnology tools.

Key topics

DNA structure and replication · transcription and translation · mutations and disease · DNA profiling and biotechnology

Assessed by

Live DNA extraction lab · video assignment · proctored unit test

Nervous system · endocrine system · urinary system · feedback mechanisms · effects of drugs

Identify the key components of the nervous, endocrine and excretory systems and their role in maintaining homeostasis, including how chemical substances and environmental factors affect these processes. Assess the impact of various drugs on homeostatic mechanisms.

Key topics

Nervous system · endocrine system · urinary system · feedback mechanisms · effects of drugs

Assessed by

Breathing rate lab report · medical condition community interview · proctored unit test

Population growth models · limiting factors · human population and sustainability · ecological footprint

Use models to calculate population growth, explain the factors that affect the growth of species populations, and analyse the relationships between population growth, personal consumption, technological development and our ecological footprint.

Key topics

Population growth models · limiting factors · human population and sustainability · ecological footprint

Assessed by

Measuring populations lab · proctored unit test

Course review · learning skills and work habits reflection

Consolidate the course ahead of the final exam with a learning-skills self-assessment and an end-of-course conversation with your teacher.

Key topics

Course review · learning skills and work habits reflection

Assessed by

End-of-course conversation and observation

SBI4U Biology
Grade 12 · University

How the final mark is calculated from September 2026

65% Coursework
25% Final written exam
5% Attendance
5% Participation
Domestic Student Fee

$595.00

International Student Fee

$895.00

ALL STUDENTS RECEIVE
24/7 Tutoring
Proctored Final Exam
Fast Track
Includes Priority Exam Scheduling

Fully online and self-paced

SBI4U

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FAQ About %course-code%.

Supported by Ontario Certified Teachers

SBI4U is the Grade 12 University-preparation biology course covering biochemistry, metabolic processes (cellular respiration and photosynthesis), molecular genetics, homeostasis, and population dynamics. It’s a core admission requirement for health-science, life-science, nursing, and kinesiology programs across Ontario. This course has been developed based on the following Ministry of Ontario Curriculum for Grade 12 Biology.

SBI4U is demanding — biochemistry and molecular genetics involve detailed processes and precise terminology, and the volume of content is significant. It rewards consistent review over cramming. OES’s self-paced format lets you take dense units like metabolic processes at your own speed, with free 24/7 tutoring included.

The prerequisite for SBI4U is SBI3U (Grade 11 Biology). Students without SBI3U should complete it first — OES offers both, and taking them in sequence with the multi-course discount is a common plan.

SBI4U is required or strongly recommended by health sciences, life sciences, nursing, kinesiology, biomedical programs, and many psychology programs, usually alongside SCH4U (Grade 12 Chemistry). If a health-related program is your target, SBI4U + SCH4U is the standard science pairing.

SBI4U covers five units: biochemistry (macromolecules, enzymes), metabolic processes (cellular respiration, photosynthesis), molecular genetics (DNA replication, protein synthesis, biotechnology), homeostasis (nervous, endocrine, and excretory systems), and population dynamics (growth, interactions, and human impact).

Competitive health-science and nursing programs typically admit in the low-80s to 90s overall, and SBI4U usually counts in that average — so treat mid-70s as a floor and aim higher for competitive programs. Retaking SBI4U to lift a mark is common, and universities use your highest grade.

Yes. OES offers a dedicated Upgrade: SBI4U course built specifically for retaking SBI4U to raise your mark — Ontario universities and colleges use your highest grade. It’s self-paced and open year-round, so you can upgrade alongside your day school, a job, or a gap year and finish in as little as 4 weeks. See the Upgrade: SBI4U page for details.

Yes. Ontario students who started Grade 9 in the 2020–21 school year or later must earn at least two online learning credits to graduate, and SBI4U at OES — a Ministry-inspected online school (BSID #667186) — counts toward that requirement. An opt-out process exists through school boards, and specific provisions apply to students affected by the 2021 school closures.

SBI4U meets the Ministry of Education’s attendance and participation expectations through activities blended directly into the course. OES requires students to log in at least once per week for attendance, and participation activities appear throughout the course and are reflected in the grade book — preserving self-paced flexibility while satisfying the requirements for online courses.

Yes — science is one of Ontario’s STEM-related course groups (business studies, computer studies, cooperative education, mathematics, science, and technological education), from which students entering Grade 9 in 2024 or later must complete one credit. For math and science, the credit counts when earned in addition to your compulsory math and science credits, so SBI4U can double as your STEM-group credit.

Ontario’s Growing Success policy pre-determines the evaluation structure for every credit. Beginning in the 2026–27 school year, SBI4U is graded on classroom work completed throughout the course (65%) plus a Ministry-mandated final evaluation worth 25% for Grades 11–12, with attendance and participation also reflected in the final grade. A credit is granted at 50% or higher — and as an inspected private school, OES may administer final evaluations online, while school-board online courses generally require in-person exam sittings.

Book a Free 15-Min Guidance Call
Domestic Student Fee

$595.00

International Student Fee

$895.00

ALL STUDENTS RECEIVE
24/7 Tutoring
Proctored Final Exam
Fast Track
Includes Priority Exam Scheduling